PPM1A Rabbit Polyclonal Antibody (ER1706-37)

UNIPROT #

P35813

PROTEIN NAME

PPM1A

SYNONYMS

Protein phosphatase 2C isoform alpha antibody;EC 3.1.3.16 antibody;FLJ42306 antibody IA antibody;MGC9201 antibody;Mpp alpha antibody;PP2C alpha antibody;PP2C-alpha antibody;PP2CA antibody;PP2Calpha antibody;PPM 1A antibody;PPM1A antibody;PPM1A_HUMAN antibody;PPPM1A antibody;Protein phosphatase 1A (formerly 2C) magnesium dependent alpha isoform antibody;Protein phosphatase 1A antibody;Protein phosphatase 1A magnesium dependent alpha antibody;Protein phosphatase 2C alpha antibody;Protein phosphatase 2C alpha isoform antibody;Protein phosphatase 2C isoform alpha antibody;Protein phosphatase IA antibody;Protein phosphatase, Mg2+/Mn2+ dependent, 1A antibody

SEQUENCE SIMILARITIES

Belongs to the PP2C family.

POST-TRANSLATIONAL MODIFICATION

N-myristoylation is essential for the recognition of its substrates for dephosphorylation.

SUBCELLULAR LOCATION

Cytoplasm, Membrane, Nucleus.

FUNCTION

The phosphorylation and dephosphorylation of proteins on serine and threonine residues is an essential means of regulating a broad range of cellular functions in eukaryotes, including division, homeostasis and apoptosis. A group of proteins that are intimately involved in this process are the serine/ threonine protein phosphatases. Protein phosphatase 2Ca (PP2Ca) has broad specificity. It dephosphorylates and negatively regulates the activities of MAP kinases and MAP kinase-kinases while also inhibiting the activation of p38 and JNK kinase cascades, induced by environmental stresses. PP2Ca also induces the expression of endogenous p53 and the p53-responsive gene p21, leading to cell cycle arrest and apoptosis. The PP2Ca protein, which contains an active site containing a dinuclear metal ion center, shows highest expression in epithelial cells, as well as in the digestive tract, lung, kidney, breast, prostate, endocrine glands and brain.