PPP3CB Recombinant Rabbit Monoclonal Antibody [PSH0-21] (HA721292)

UNIPROT #

P16298

PROTEIN NAME

PPP3CB

SYNONYMS

Calcineurin A beta antibody;Calcineurin A2 antibody;Calcineurin B, formerly antibody;Calmodulin dependent calcineurin A subunit beta isoform antibody;Calmodulin-dependent calcineurin A subunit beta isoform antibody;CALNA 2 antibody;CALNA2 antibody;CALNB antibody;CAM PRP catalytic subunit antibody;CAM-PRP catalytic subunit antibody;CNA2 antibody;CnAbeta antibody;PP2BB_HUMAN antibody;PP2Bbeta antibody;PPP3CB antibody;Protein phosphatase 2B, catalytic subunit, beta isoform, formerly antibody;Protein phosphatase 3 (formerly 2B) catalytic subunit beta isoform antibody;Protein phosphatase 3 catalytic subunit beta isoform antibody;Protein phosphatase 3 catalytic subunit beta isozyme antibody;Serine/threonine protein phosphatase 2B catalytic subunit beta isoform antibody;Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform antibody

SUBCELLULAR LOCATION

Cytoplasm

FUNCTION

Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca2+-mediated signals. Dephosphorylates and activates transcription factor NFATC1. Dephosphorylates and inactivates transcription factor ELK1.Dephosphorylates DARPP32. Negatively regulates MAP3K14/NIK signaling via inhibition of nuclear translocation of the transcription factors RELA and RELB. May play a role in skeletal muscle fiber type specification. Forms a complex composed of a calmodulin-dependent catalytic subunit (also known as calcineurin A) and a regulatory Ca2+-binding subunit (also known as calcineurin B). There are three catalytic subunits, each encoded by a separate gene (PPP3CA, PPP3CB, and PPP3CC) and two regulatory subunits which are also encoded by separate genes (PPP3R1 and PPP3R2). In response to an increase in Ca2+ intracellular levels, forms a complex composed of PPP3CB/calcineurin A, calcineurin B and calmodulin. Interacts (via calcineurin B binding domain) with regulatory subunit PPP3R1/calcineurin B. Interacts (via calmodulin-binding domain) with calmodulin; the interaction depends on calmodulin binding to Ca2+. Interacts with SLC12A1.