PRDM14 Rabbit Polyclonal Antibody (R1310-4)

UNIPROT #

Q9GZV8

PROTEIN NAME

PRDM14

SYNONYMS

MGC59730 antibody;PFM 11 antibody;PFM11 antibody;PR domain containing 14 antibody;PR domain zinc finger protein 14 antibody;PR domain-containing protein 14 antibody;PRD14_HUMAN antibody;PRDM 14 antibody;PRDM14 antibody

SEQUENCE SIMILARITIES

Belongs to the class V-like SAM-binding methyltransferase superfamily.

TISSUE SPECIFICITY

Expressed in embryonic stem cells. Tends to be overexpressed in breast cancer (at protein level).

SUBCELLULAR LOCATION

Nucleus

FUNCTION

PR domain zinc finger protein 14 is a transcription factor that has both positive and negative roles on transcription. It is expressed in embryonic stem cells and tends to be overexpressed in breast cancer. PRDM14 is required for the maintenance of emryonic stem cell identity and the reacquisition of pluripotency in somatic cells. It may play an essential role in germ cell development at 2 levels: the reacquisition of potential pluripotency, including SOX2 up-regulation, and successful epigenetic reprogramming, characterized by EHMT1 repression. PRDM14 directly up-regulates the expression of pluripotency gene POU5F1 through its proximal enhancer.