Profilin 1 Recombinant Rabbit Monoclonal Antibody [JA30-13] (ET1704-42)

UNIPROT #

P07737

PROTEIN NAME

Profilin 1

SYNONYMS

Actin binding protein antibody;ALS18 antibody;Epididymis tissue protein Li 184a antibody;OTTHUMP00000125244 antibody;PFN 1 antibody;Pfn antibody;PFN1 antibody;PROF1_HUMAN antibody;Profilin I antibody;Profilin-1 antibody;Profilin1 antibody;ProfilinI antibody

SEQUENCE SIMILARITIES

Belongs to the profilin family.

TISSUE SPECIFICITY

Expressed in epididymis (at protein level).

POST-TRANSLATIONAL MODIFICATION

Phosphorylation at Ser-138 reduces its affinity for G-actin and blocks its interaction with HTT, reducing its ability to inhibit androgen receptor (AR) and HTT aggregation.

SUBCELLULAR LOCATION

Cytoskeleton.

FUNCTION

Profilins regulate Actin polymerization by binding to and sequestering the Actin monomer. Profilins act as a nucleotide exchange factor that charges Actin with ATP after binding the Actin monomer through a 1:1 stoichiometric relationship. Human Profilin-1 and Profilin-2 are encoded by two separate genes mapping to chromosomes 17p13.2 and 3q25.1, respectively. Both Profilin-1 and Profilin-2 are abundantly expressed in kidney. Profilin-1 is highly expressed in lung, liver, placenta and kidney while Profilin-2 is highly expressed in brain and skeletal muscle. In axonal and dendritic processes of mouse brain, Profilins co-localize with dynamin I and synapsin. Profilin may play a role in mediating cell adhesion. The overexpression of Profilin in endothelial cells results in increased adhesion to Fibronectin. In food allergy, plant Profilin is considered a pan-allergen. Case studies indicate individuals with allergies to various foods including celery, carrots, zucchini and peanuts are actually sensitive to the Profilin proteins in these foods.