PSIP1 Recombinant Rabbit Monoclonal Antibody [JE75-02] (HA721540)

UNIPROT #

O75475

PROTEIN NAME

PSIP1

SYNONYMS

CLL associated antigen KW 7 antibody;CLL-associated antigen KW-7 antibody;Dense fine speckles 70 kDa protein antibody;DFS 70 antibody;DFS70 antibody;LEDGF antibody;Lens epithelium derived growth factor antibody;Lens epithelium-derived growth factor antibody;MGC74712 antibody;p52 antibody;p75 antibody;PAIP antibody;PC4 and SFRS1 interacting protein 1 antibody;PC4 and SFRS1 interacting protein 2 antibody;PC4 and SFRS1 interacting protein antibody;PC4 and SFRS1-interacting protein antibody;PSIP 1 antibody;PSIP 2 antibody;Psip1 antibody;PSIP1_HUMAN antibody;PSIP2 antibody;Transcriptional coactivator p75/p52 antibody

SUBCELLULAR LOCATION

Nucleus.

FUNCTION

PC4 and SFRS1 interacting protein 1, also known as lens epithelium-derived growth factor (LEDGF/p75), dense fine speckles 70kD protein (DFS 70) or transcriptional coactivator p75/p52, is a protein that in humans is encoded by the PSIP1 gene. PSIP1 has not been clearly linked to a specific cellular mechanism. The term LEDGF/p75 (Lens epithelium-derived growth factor) has entered common usage based on the initial characterization of PSIP1, however this is a misnomer, as the protein is present in most tissues and has no direct role in the development of lens epithelium. LEDGF/p75, a transcription coactivator, gained prominence as a host factor that assists HIV integration and is probably the only integrase interactor whose knock-down severely affects the HIV integration levels. The interaction between HIV integrase and human LEDGF/p75 is a promising target for anti-HIV drug discovery. LEDGF/p75 recruits MLL complexes to HOX genes to regulate their expression. LEDGF/p52 is shown to recruit splicing factors to H3K36 trimethylated chromatin to modulate alternative splicing, also regulates HOTTIP lncRNA, which is shown to regulate HOX genes in cis.