PSMA Mouse Monoclonal Antibody [A5F12] (HA600046)

UNIPROT #

Q04609

PROTEIN NAME

PSMA

SYNONYMS

Cell growth inhibiting protein 27 antibody;Cell growth-inhibiting gene 27 protein antibody;FGCP antibody;Folate hydrolase (prostate-specific membrane antigen) 1 antibody;Folate hydrolase 1 antibody;Folate hydrolase antibody;Folate hydrolase prostate specific membrane antigen 1 antibody;FOLH 1 antibody;FOLH antibody;Folh1 antibody;FOLH1_HUMAN antibody;Folylpoly gamma glutamate carboxypeptidase antibody;Folylpoly-gamma-glutamate carboxypeptidase antibody;GCP 2 antibody;GCP II antibody;GCP2 antibody;GCPII antibody;GIG27 antibody;Glutamate carboxylase II antibody;Glutamate carboxypeptidase 2 antibody;Glutamate carboxypeptidase II antibody;Membrane glutamate carboxypeptidase antibody;mGCP antibody;N acetylated alpha linked acidic dipeptidase 1 antibody;N-acetylated-alpha-linked acidic dipeptidase I antibody;NAALAD 1 antibody;NAALAD1 antibody;NAALAdase antibody;NAALADase I antibody;Prostate specific membrane antigen antibody;Prostate specific membrane antigen variant F antibody;Prostate-specific membrane antigen antibody;PSM antibody;PSMA antibody;Pteroylpoly gamma glutamate carboxypeptidase antibody;Pteroylpoly-gamma-glutamate carboxypeptidase antibody

SUBCELLULAR LOCATION

Cell membrane, Cytoplasm.

FUNCTION

This gene encodes a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on different alternative substrates, including the nutrient folate and the neuropeptide N-acetyl-l-aspartyl-l-glutamate and is expressed in a number of tissues such as prostate, central and peripheral nervous system and kidney. A mutation in this gene may be associated with impaired intestinal absorption of dietary folates, resulting in low blood folate levels and consequent hyperhomocysteinemia. Expression of this protein in the brain may be involved in a number of pathological conditions associated with glutamate excitotoxicity. In the prostate the protein is up-regulated in cancerous cells and is used as an effective diagnostic and prognostic indicator of prostate cancer. This gene likely arose from a duplication event of a nearby chromosomal region. Alternative splicing gives rise to multiple transcript variants encoding several different isoforms.