PSMC5 Recombinant Rabbit Monoclonal Antibody [PSH0-22] (HA721301)

UNIPROT #

P62195

PROTEIN NAME

PSMC5

SYNONYMS

26S protease regulatory subunit 8 antibody;26S proteasome AAA-ATPase subunit RPT6 antibody;Cim3 antibody;MSUG1 protein antibody;p45 antibody;p45/SUG antibody;Proteasome 26S ATPase subunit 5 antibody;Proteasome 26S subunit ATPase 5 antibody;Proteasome prosome macropain 26S subunit ATPase 5 antibody;Proteasome subunit p45 antibody;PRS8_HUMAN antibody;PSMC5 antibody;Rpt6 antibody;S8 antibody;SUG1 antibody;Tat binding protein homolog 10 antibody;TBP10 antibody;Thyroid hormone receptor interacting protein 1 antibody;Thyroid hormone receptor-interacting protein 1 antibody;Thyroid receptor interactor 1 antibody;TRIP1 antibody;TRIP1(SUG1) antibody

SUBCELLULAR LOCATION

Cytoplasm, Nucleus.

FUNCTION

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. In addition to participation in proteasome functions, this subunit may participate in transcriptional regulation since it has been shown to interact with the thyroid hormone receptor and retinoid X receptor-alpha. Two transcript variants encoding different isoforms have been found for this gene.