PSMD4 Rabbit Polyclonal Antibody (HA500390)

UNIPROT #

P55036

PROTEIN NAME

PSMD4

SYNONYMS

26S protease subunit S5a antibody;26S proteasome non ATPase regulatory subunit 4 antibody;26S proteasome non-ATPase regulatory subunit 4 antibody;26S proteasome regulatory subunit rpn10 antibody;26S proteasome regulatory subunit S5A antibody;AF 1 antibody;AF antibody;AF1 antibody;Angiocidin antibody;Antisecretory factor 1 antibody;ASF antibody;DS5a antibody;MCB 1 antibody;MCB1 antibody;Multiubiquitin chain binding protein antibody;Multiubiquitin chain-binding protein antibody;OTTHUMP00000059963 antibody;Prosome macropain antibody;Proteasome (prosome macropain) 26S subunit non ATPase 4 antibody;Proteasome 19S S5A antibody;Proteasome 26S non ATPase subunit 4 antibody;Proteasome 26S subunit non ATPase 4 antibody;PSMD 4 antibody;Psmd4 antibody;PSMD4_HUMAN antibody;pUB R5 antibody;pUBR5 antibody;Rpn 10 antibody;Rpn10 antibody;RPN10 homolog antibody;S5A antibody;S5a/antisecretory factor protein antibody

SUBCELLULAR LOCATION

Cytosol, Nucleus.

FUNCTION

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the non-ATPase subunits of the 19S regulator lid. Pseudogenes have been identified on chromosomes 10 and 21. Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMD4 acts as an ubiquitin receptor subunit through ubiquitin-interacting motifs and selects ubiquitin-conjugates for destruction. Displays a preferred selectivity for longer polyubiquitin chains.