PSMD6 Mouse Monoclonal Antibody [A9E4] (HA601127)

UNIPROT #

Q15008

PROTEIN NAME

PSMD6

SYNONYMS

26S proteasome non-ATPase regulatory subunit 6 antibody;26S proteasome regulatory subunit RPN7 antibody;26S proteasome regulatory subunit S10 antibody;Breast cancer-associated protein SGA-113M antibody;KIAA0107 antibody;p42A antibody;P44S10 antibody;PFAAP4 antibody;Phosphonoformate immuno-associated protein 4 antibody;Proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 antibody;Proteasome regulatory particle subunit p44S10 antibody;PSMD6 antibody;PSMD6_HUMAN antibody;Rpn7 antibody;S10 antibody;SGA-113M antibody

SUBCELLULAR LOCATION

Cytosol, extracellular region, nucleoplasm.

FUNCTION

This gene encodes a member of the protease subunit S10 family. The encoded protein is a subunit of the 26S proteasome which colocalizes with DNA damage foci and is involved in the ATP-dependent degradation of ubiquinated proteins. Alternative splicing results in multiple transcript variants. Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.