PTGER2 Recombinant Rabbit Monoclonal Antibody [JE30-72] (HA721380)

UNIPROT #

P43116

PROTEIN NAME

PTGER2

SYNONYMS

EP2 antibody;PE2R2_HUMAN antibody;PGE receptor EP2 subtype antibody;PGE2 receptor EP2 subtype antibody;Prostaglandin E receptor 2 EP2 subtype antibody;Prostaglandin E receptor 2 subtype EP2 53kDa antibody;Prostaglandin E receptor 2 subtype EP2 antibody;Prostaglandin E2 receptor antibody;Prostaglandin E2 receptor EP2 subtype antibody;Prostanoid EP2 receptor antibody;Ptger2 antibody

SUBCELLULAR LOCATION

Cell membrane.

FUNCTION

EP2 is widely distributed in humans. Its protein is expressed in human small intestine, lung, media of arteries and arterioles of the kidney, thymus, uterus, brain cerebral cortex, brain striatum, brain hippocampus, corneal epithelium, corneal choriocapillaries, Myometriuml cells, eosinophiles, sclera of the eye, articular cartilage, the corpus cavernosum of the penis, and airway smooth muscle cells; its mRNA is expressed in gingival fibroblasts, monocyte-derived dendritic cells, aorta, corpus cavernosum of the penis, articular cartilage, airway smooth muscle, and airway epithelial cells. In rats, the receptor protein and/or mRNA has been found in lung, spleen, intestine, skin, kidney, liver, long bones, and rather extensively throughout the brain and other parts of the central nervous system. EP2 expression in fibroblasts from the lungs of mice with bleomycin-induced pulmonary fibrosis and humans with Idiopathic pulmonary fibrosis is greatly reduced. In both instances, this reduced expression was associated with hypermethylation of CpG dinucleotide sites located in the first 420 base pairs upstream of the PTGER2 gene transcription start site of these fibroblasts. This suggests that EP2 expression is regulated by this methylation.