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Pygopus 2 Rabbit Polyclonal Antibody (R1510-27)

Price: Regular price $315.00

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Catalog# R1510-27

Rabbit Polyclonal to Pygopus 2

Tested for

  • WB

  • FC

Reacts with

  • Human

  • Mouse

Specifications

Product Type

Rabbit polyclonal primary

Product Name

Pygopus 2 Rabbit Polyclonal Antibody (R1510-27)

Immunogen

Synthetic peptide within human pygopus aa 31-80 / 406.

Host

Rabbit

Positive Control

Hela, NCCIT.

Conjugation

Unconjugated

Clonality

Polyclonal

RRID

AB_3073335

APPLICATION DILUTION

  • WB

  • 1:1,000

  • FC

  • 1:50-1:100

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1ug/ul

Purification

Immunogen affinity purified.

Molecular Weight

41kDa

Isotype

IgG

TARGET

UNIPROT #

Q9BRQ0

PROTEIN NAME

Pygopus 2

SYNONYMS

1190004M21Rik antibody;FLJ33226 antibody;PP7910 antibody;PYGO2 antibody;Pygo2 protein antibody;PYGO2_HUMAN antibody;Pygopus 2 antibody;pygopus homolog 2 (Drosophila) antibody;Pygopus homolog 2 antibody

SUBCELLULAR LOCATION

Nucleus

FUNCTION

Pygopus 2, also known as PYGO2, is a 406 amino acid protein that is the human homolog of the Drosophila pygopus protein. Localized to the nucleus, Pygopus 2 contains one PHD finger that interacts with the homology domain of the Wnt signaling protein Bcl-9. This interaction joins Pygopus 2 with the ∫-catenin/TCF complex (a crucial complex in Wnt signaling), thereby allowing ∫-catenin to transcriptionally activate Wnt target genes. Association of Pygopus 2 with proteins involved in the Wnt signaling pathway is thought to regulate proper signal transduction, as absence of the Pygopus 2/∫-catenin interaction may play a role in development of B-cell malignancies. In addition, Pygopus 2 expression is upregulated in and required for the growth of breast cancer cells, suggesting a crucial role in carcinogenesis.

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