Rab5 Recombinant Rabbit Monoclonal Antibody [ST47-04] (ET1609-27)

UNIPROT #

P20339

PROTEIN NAME

Rab5

SYNONYMS

RAB 5 antibody;RAB 5A antibody;RAB5A antibody;RAB5A member RAS oncogene family antibody;RAB5A_HUMAN antibody;RAS associated protein RAB5A antibody;Ras related protein Rab 5A antibody;Ras-related protein Rab-5A antibody

SEQUENCE SIMILARITIES

Belongs to the small GTPase superfamily. Rab family.

POST-TRANSLATIONAL MODIFICATION

Phosphorylation of Ser-84 in the switch II region by LRRK2 prevents the association of RAB regulatory proteins, including RAB GDP dissociation inhibitors GDI1 and GDI2.

SUBCELLULAR LOCATION

Cell membrane, Cytoplasm, Cell projection, Membrane, Endosome.

FUNCTION

The Ras-related superfamily of guanine nucleotide binding proteins, which includes the R-Ras, Rap, Ral/Rec and Rho/Rab subfamilies, exhibit 30-60% homology with Ras p21. Accumulating data suggests an important role for Rab proteins, either in endocytosis or in biosynthetic protein transport. The transport of newly synthesized proteins from the endoplasmic reticulum to various stacks of the Golgi complex and to secretory vesicles involves at each stage the movement of carrier vesicles, a process that appears to involve Rab protein function. The possibility that Rab proteins might also direct the exocytosis from secretory vesicles to the plasma membrane is supported by the observation that in yeast, the Sec4 protein, which is 40% homologous to Rab proteins, is associated with secretory vesicles. At least eight members of the Rab subfamily have been identified, each of which is found at a particular stage of a membrane transport pathway.