RAC1/2/3 Rabbit Polyclonal Antibody (HA500424)

UNIPROT #

P15153

PROTEIN NAME

RAC1/2/3

SYNONYMS

OTTMUSP00000004488 antibody;p21 Rac3 antibody;p21-Rac3 antibody;Rac1B antibody;RAC3 antibody;RAC3_HUMAN antibody;RAS related C3 botulinum substrate 3 antibody;Ras related C3 botulinum toxin substrate 3 (rho family small GTP binding protein Rac3) antibody;Ras related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) antibody;Ras-related C3 botulinum toxin substrate 3 antibody;Rho family small GTP binding protein Rac3 antibody;RP23-84C12.18 antibody

SUBCELLULAR LOCATION

Cytoplasm, Cytoplasm, Cell membrane.

FUNCTION

Rac1 function: Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization and growth-factor induced formation of membrane ruffles. Rac2 fucntion: Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as secretory processes, phagocytose of apoptotic cells and epithelial cell polarization. Augments the production of reactive oxygen species (ROS) by NADPH oxidase. Enzyme regulation: Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP, GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity, and GDP dissociation inhibitors which inhibit the dissociation of the nucleotide from the GTPase. Rac3 function: Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as cell spreading and the formation of actin-based protusions including lamellipodia and membrane ruffles. Promotes cell adhesion and spreading on fibrinogen in a CIB1 and alpha-IIb/beta3 integrin-mediated manner.