Rae1 Rabbit Polyclonal Antibody (ER1802-61)

UNIPROT #

P78406

PROTEIN NAME

Rae1

SYNONYMS

dJ481F12.3 antibody;dJ800J21.1 antibody;FLJ30608 antibody;Homolog of yeast Rae1 (Bharathi) mRNA associated protein of 41 kDa (Kraemer) antibody;Homolog of yeast Rae1 mRNA associated protein of 41 kDa antibody;MGC117333 antibody;MGC126076 antibody;MGC126077 antibody;MIG 14 antibody;MIG14 antibody;Migration inducing gene 14 antibody;Mnrp 41 antibody;Mnrp41 antibody;mRNA associated protein mrnp 41 antibody;mRNA binding protein 41 kD antibody;mRNA export factor antibody;mRNA export protein antibody;mRNA-associated protein mrnp 41 antibody;MRNP 41 antibody;MRNP41 antibody;RAE 1 antibody;RAE1 (RNA export 1 S.pombe) homolog antibody;rae1 antibody;RAE1 homolog antibody;Rae1 protein homolog antibody;RAE1 RNA export 1 homolog (S. pombe) antibody;RAE1 RNA export 1 homolog antibody;RAE1L_HUMAN antibody;RNA export 1 antibody;RNA export 1 homolog antibody

SEQUENCE SIMILARITIES

Belongs to the WD repeat rae1 family.

SUBCELLULAR LOCATION

Cytoplasm, Nucleus, Cytoplasm, cytoskeleton, spindle pole, Nucleus envelope.

FUNCTION

Mrnp41 (mRNA-binding protein, 41-KD), also known as Rae1 protein homolog and mRNA export factor, is a 368 amino acid protein that binds mRNA and is involved in nucleocytoplasmic transport. Though characterized in both the nucleus and cytoplasm, mrnp41 is primarily localized to the nuclear pore complex in the nuclear envelope. Mutations in mrnp41 may result in the accumulation of poly(A)-containing mRNA in the nucleus, further supporting the role of mrnp41 as a primary nuclear exporter of mRNA. Along with Nup98, mrnp41 has been shown to regulate E-cadherin, an activating subunit of the anaphase-promoting complex complex, which results in the prevention of securin degradation, therefore suggesting that mrnp41 may play a potential role in maintaining euploidy. Also, during mitosis, both mrnp41 and NuMA have been shown to be required for bipolar spindle formation.