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RANTES Recombinant Rabbit Monoclonal Antibody [JM03-45] (ET1705-70)

Price: Regular price $385.00

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Catalog# ET1705-70

Rabbit Monoclonal to RANTES

Tested for

  • WB

  • IHC-P

  • IF-Cell

  • IF-Tissue

Reacts with

  • Human

  • Mouse

Recombinant production enables lot-to-lot consistency and is animal-cruelty-free
This product has been cited in peer reviewed publications, see list HERE

Specifications

Product Type

Recombinant Rabbit monoclonal primary

Product Name

RANTES Recombinant Rabbit Monoclonal Antibody [JM03-45] (ET1705-70)

Immunogen

Recombinant protein within human rantes aa 1-91.

Host

Rabbit

Positive Control

Mouse thymus lysates, Hela, HUVEC, human tonsil tissue, human placenta tissue.

Conjugation

Unconjugated

Clonality

Monoclonal

Clone Number

JM03-45

RRID

AB_3070600

APPLICATION DILUTION

  • WB

  • 1:500-1:1,000

  • IF-Cell

  • 1:50-1:200

  • IF-Tissue

  • 1:50-1:200

  • IHC-P

  • 1:50-1:200

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1ug/ul

Purification

Protein A affinity purified.

Molecular Weight

Predicted band size: 10 kDa

Isotype

IgG

TARGET

UNIPROT #

P13501

PROTEIN NAME

RANTES

SYNONYMS

Beta chemokine RANTES antibody;Beta chemokine RANTES precursor antibody;C C motif chemokine 5 antibody;CCL 5 antibody;CCL5 antibody;CCL5_HUMAN antibody;Chemokine (C C motif) ligand 5 antibody;Chemokine CC Motif Ligand 5 antibody;D17S136E antibody;EoCP antibody;Eosinophil chemotactic cytokine antibody;MGC17164 antibody;RANTES(4-68) antibody;Regulated upon activation normally T expressed and presumably secreted antibody;SCYA 5 antibody;SCYA5 antibody;SIS delta antibody;SIS-delta antibody;SISd antibody;Small inducible cytokine A5 (RANTES) antibody;Small inducible cytokine A5 antibody;Small inducible cytokine subfamily A (Cys Cys) member 5 antibody;Small-inducible cytokine A5 antibody;T cell specific protein p288 antibody;T cell specific RANTES protein antibody;T cell-specific protein P228 antibody;T-cell-specific protein RANTES antibody;TCP 228 antibody;TCP228 antibody

SEQUENCE SIMILARITIES

Belongs to the intercrine beta (chemokine CC) family.

TISSUE SPECIFICITY

Expressed in the follicular fluid (at protein level). T-cell and macrophage specific.

POST-TRANSLATIONAL MODIFICATION

N-terminal processed form RANTES(3-68) is produced by proteolytic cleavage, probably by DPP4, after secretion from peripheral blood leukocytes and cultured sarcoma cells.; The identity of the O-linked saccharides at Ser-27 and Ser-28 are not reported in PubMed:1380064. They are assigned by similarity.

SUBCELLULAR LOCATION

Secreted.

FUNCTION

Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. Binds to CCR1, CCR3, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant RANTES protein induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form RANTES(3-68) acts as a natural chemotaxis inhibitor and is a more potent inhibitor of HIV-1-infection. The second processed form RANTES(4-68) exhibits reduced chemotactic and HIV-suppressive activity compared with RANTES(1-68) and RANTES(3-68) and is generated by an unidentified enzyme associated with monocytes and neutrophils.

CITATIONS

  • Che, L. H., Liu, J. W., Huo, J. P., Luo, R., Xu, R. M., He, C., Li, Y. Q., Zhou, A. J., Huang, P., Chen, Y. Y., Ni, W., Zhou, Y. X., Liu, Y. Y., Li, H. Y., Zhou, R., Mo, H., & Li, J. M.

    A single-cell atlas of liver metastases of colorectal cancer reveals reprogramming of the tumor microenvironment in response to preoperative chemotherapy

  • Wang Ke,et al

    CD147‐K148me2‐Driven Tumor Cell‐Macrophage Crosstalk Provokes NSCLC Immunosuppression via the CCL5/CCR5 Axis

  • Huang Jiaxing,et al

    YY1 Lactylation Aggravates Autoimmune Uveitis by Enhancing Microglial Functions via Inflammatory Genes

  • Single-cell transcriptome analysis and protein profiling reveal broad immune system activation in IgG4-related disease

  • Hu, W., Chen, J., Qi, L., Ge, W., Zheng, S., & Yang, Y.

    Hypermutated tumours across 11 cancer types show three distinct immune subtypes

  • Zhao, P., Liu, X., Wang, Y., Zhang, X., Wang, H., Du, X., Du, Z., Yang, L., & Hou, J.

    Discovery of grey matter lesion-related immune genes for diagnostic prediction in multiple sclerosis

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