RAP80 Mouse Monoclonal Antibody [A1B11] (EM1902-05)

UNIPROT #

Q96RL1

PROTEIN NAME

RAP80

SYNONYMS

BRCA1-A complex subunit RAP80 antibody;Nuclear zinc finger protein RAP80 antibody;OTTHUMP00000161441 antibody;OTTHUMP00000223372 antibody;OTTHUMP00000223374 antibody;RAP80 antibody;Receptor associated protein 80 antibody;Receptor-associated protein 80 antibody;Retinoid X receptor interacting protein 110 antibody;Retinoid x receptor interacting protein antibody;Retinoid X receptor-interacting protein 110 antibody;RIP110 antibody;Rxrip110 antibody;Ubiquitin interaction motif containing 1 antibody;Ubiquitin interaction motif containing protein 1 antibody;Ubiquitin interaction motif-containing protein 1 antibody;UIMC1 antibody;UIMC1_HUMAN antibody;X2HRIP110 antibody

SEQUENCE SIMILARITIES

Belongs to the RAP80 family.

TISSUE SPECIFICITY

Expressed in testis, ovary, thymus and heart. Expressed in germ cells of the testis.

POST-TRANSLATIONAL MODIFICATION

Sumoylated.; Phosphorylated upon DNA damage by ATM or ATR.

SUBCELLULAR LOCATION

Nucleus.

FUNCTION

Ubiquitin-binding protein. Specifically recognizes and binds 'Lys-63'-linked ubiquitin. Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin. May interact with monoubiquitinated histones H2A and H2B; the relevance of such results is however unclear in vivo. Does not bind Lys-48'-linked ubiquitin. May indirectly act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1.