RBP4 Recombinant Rabbit Monoclonal Antibody [JA33-10] (ET1704-86)

UNIPROT #

P02753

PROTEIN NAME

RBP4

SYNONYMS

OTTHUMP00000020114 antibody;OTTHUMP00000020115 antibody;OTTHUMP00000020116 antibody;Plasma retinol binding protein 4 antibody;Plasma retinol-binding protein antibody;Plasma retinol-binding protein(1-176) antibody;PRBP antibody;PRO2222 antibody;RBP antibody;RBP4 antibody;RDCCAS antibody;RET4_HUMAN antibody;Retinol binding protein 4 antibody;Retinol binding protein 4 interstitial antibody;Retinol binding protein 4 plasma antibody

SEQUENCE SIMILARITIES

Belongs to the calycin superfamily. Lipocalin family.

TISSUE SPECIFICITY

Detected in blood plasma and in urine (at protein level).

SUBCELLULAR LOCATION

Secreted.

FUNCTION

Retinol (Vitamin A) is transported in the blood bound to its carrier protein, retinol-binding protein (RBP), also designated plasma retinol-binding protein (PRBP) or RBP4. A member of the lipocalin family, RBP conveys retinol from stores in the liver to peripheral tissues. In plasma, RBP binds transthyretin (TTR, formerly called prealbumin) to prevent glomerular filtration of low molecular weight RBP in the kidneys. The stability of this complex holds diagnostic importance because the molar ratio of RBP:TTR provides an indirect way to indicate marginal vitamin A deficiency. Vitamin A deficiency blocks the secretion of RBP resulting in defective delivery and supply to epidermal cells. Originally identified solely as a transporter protein, recent studies correlating increased levels of RBP expression in adipose tissue with insulin resistance have generated research into the possible roles the protein