RNase L Recombinant Rabbit Monoclonal Antibody [JE36-11] (HA722221)

UNIPROT #

Q05823

PROTEIN NAME

RNase L

SYNONYMS

2 5A dependent ribonuclease antibody;2 5A dependent RNase antibody;2' 5' oligoisoadenylate synthetase dependent antibody;2-5A-dependent ribonuclease antibody;2-5A-dependent RNase antibody;DKFZp781D08126 antibody;Interferon induced 2 5A dependent RNase antibody;MGC104972 antibody;MGC133329 antibody;PRCA 1 antibody;PRCA1 antibody;Ribonuclease 4 antibody;Ribonuclease L (2' 5' oligoisoadenylate synthetase dependent) antibody;Ribonuclease L antibody;Ribonuclease4 antibody;RibonucleaseL antibody;RN5A_HUMAN antibody;RNase L antibody;Rnasel antibody;RNS 4 antibody;RNS4 antibody

SUBCELLULAR LOCATION

Cytoplasm, Mitochondrion.

FUNCTION

Ribonuclease L or RNase L (for latent), known sometimes as ribonuclease 4 or 2'-5' oligoadenylate synthetase-dependent ribonuclease, is an interferon (IFN)-induced ribonuclease which, upon activation, destroys all RNA within the cell (both cellular and viral). RNase L is an enzyme that in humans is encoded by the RNASEL gene. This gene encodes a component of the interferon-regulated 2'-5'oligoadenylate (2'-5'A) system that functions in the antiviral and antiproliferative roles of interferons. RNase L is activated by dimerization, which occurs upon 2'-5'A binding, and results in cleavage of all RNA in the cell. This can lead to activation of MDA5, an RNA helicase involved in the production of interferons.