RNF20 Recombinant Rabbit Monoclonal Antibody [SP00-47] (ET1604-4)

UNIPROT #

Q5VTR2

PROTEIN NAME

RNF20

SYNONYMS

BRE1 A antibody;BRE1 antibody;BRE1 E3 ubiquitin ligase homolog antibody;BRE1-A antibody;BRE1A antibody;BRE1A_HUMAN antibody;E3 ubiquitin-protein ligase BRE1A antibody;hBRE1 antibody;Homolog of S. cerevisiae BRE1 antibody;RING finger protein 20 antibody;Ring finger protein 20 E3 ubiquitin protein ligase antibody;Rnf20 antibody

SEQUENCE SIMILARITIES

Belongs to the BRE1 family.

TISSUE SPECIFICITY

Expressed in the normal brain and also in malignant gliomas (at protein level).

SUBCELLULAR LOCATION

Nucleus.

FUNCTION

Ubiquitination is an important mechanism through which three classes of enzymes act in concert to target short-lived or abnormal proteins for destruction. The three classes of enzymes involved in ubiquitination are the ubiquitin-activating enzymes (E1s), the ubiquitin-conjugating enzymes (E2s) and the ubiquitin-protein ligases (E3s). RNF20 (ring finger protein 20), also known as BRE1, BRE1A or hBRE1, is a 975 amino acid nuclear protein that belongs to the BRE1 family. As a component of the RNF20/40 complex, RNF20 functions as an E3 ubiquitin-protein ligase that regulates the monoubiquitination and subsequent degradation of select residues on target proteins, such as Histone H2B. RNF20 is required for transcriptional activation of Hox genes and is most likely recruited by p53 to the MDM2 promoter, thereby acting as a transcriptional co-activator. RNF20 contains one zinc finger domain and exists as a homodimer.