S100 alpha 6 Recombinant Rabbit Monoclonal Antibody [JF0976] (ET1702-28)

UNIPROT #

P06703

PROTEIN NAME

S100 alpha 6

SYNONYMS

2A9 antibody;5B10 antibody;CABP antibody;CACY antibody;Calcyclin antibody;Growth factor inducible protein 2A9 antibody;Growth factor-inducible protein 2A9 antibody;MLN 4 antibody;MLN4 antibody;OTTHUMP00000015472 antibody;OTTHUMP00000015473 antibody;PRA antibody;PRAGrowth factor inducible protein 2A9 antibody;Prolactin receptor associated protein antibody;Prolactin receptor-associated protein antibody;Protein S100 A6 antibody;Protein S100-A6 antibody;S100 A6 antibody;S100 calcium binding protein A6 (calcyclin) antibody;S100 calcium binding protein A6 antibody;S100 calcium-binding protein A6 antibody;S100A6 antibody;S10A6_HUMAN antibody

SEQUENCE SIMILARITIES

Belongs to the S-100 family.

POST-TRANSLATIONAL MODIFICATION

The N-terminus is blocked.

SUBCELLULAR LOCATION

Nucleus envelope, Cytoplasm, Cell membrane.

FUNCTION

Calcyclin, also known as Prolactin receptor-associated protein (PRA), growth factor-inducible protein 2A9, S-100 calcium-binding protein A6 (S-100A6) or MLN 4, is a homodimeric member of the S-100 calcium-binding protein family whose expression is upregulated in proliferating and differentiating cells. Calcyclin is inducible by growth factors and overexpressed in acute myeloid leukemias. It is expressed in a cell-specific manner in subpopulations of neurons and astrocytes and in epithelial cells and fibroblasts. Calcyclin is a specific target of S-100B protein in vivo. The binding of Calcyclin to S-100B is stabilized by S-100B-bound calcium and zinc. Calcyclin associates with both Annexin XI and CacyBP (calcyclin-binding protein). It functions to activate several processes along the calcium signal transduction pathway including the regulation of cell growth, proliferation, secretion and exocytosis.