SAP97 Recombinant Rabbit Monoclonal Antibody [JE39-74] (HA721502)

UNIPROT #

Q12959

PROTEIN NAME

SAP97

SYNONYMS

Discs large homolog 1 antibody;discs large, Drosophila, homolog of, 1 antibody;discs, large homolog 1 (Drosophila) antibody;Disks large homolog 1 antibody;dJ1061C18.1.1 antibody;DKFZp761P0818 antibody;DKFZp781B0426 antibody;DLG 1 antibody;DLG1 antibody;DLG1_HUMAN antibody;DLGH 1 antibody;DLGH1 antibody;hDlg antibody;Presynaptic protein SAP97 antibody;SAP 97 antibody;SAP-97 antibody;SAP97 antibody;Synapse associated protein 97 antibody;Synapse-associated protein 97 antibody

SUBCELLULAR LOCATION

Membrane, Basolateral cell membrane, Endoplasmic reticulum membrane, Postsynaptic density, Synapse, Cell membrane, sarcolemma, Apical cell membrane, Cell junction, Cytoplasm.

FUNCTION

Discs large homolog 1 (DLG1), also known as synapse-associated protein 97 or SAP97, is a scaffold protein that in humans is encoded by the SAP97 gene. SAP97 is a mammalian MAGUK-family member protein that is similar to the Drosophila protein Dlg1 (the protein is alternatively referred to as hDlg1, and the human gene is DLG1). SAP97 is expressed throughout the body in epithelial cells. In the brain it is involved in the trafficking of ionotropic receptors from the endoplasmic reticulum to the plasma membrane, and may be involved in the trafficking AMPAR during synaptic plasticity. SAP97 is expressed throughout the body in epithelial cells, including the kidney and brain. There is some evidence that SAP97 regulates cell-to-cell adhesion during cell death, and may interact with HPV. In the brain, SAP97's function is involved in the trafficking of transmembrane receptors from the ER to the plasma membrane. SAP97's function has been investigated by reducing its expression by knockout or increasing its expression heterologously. Mice in which the SAP97 gene has been knocked out die perinatally, have a cleft palate, and deficiencies in renal function. Overexpression of SAP97 in mammalian neurons leads to increased synaptic strength.