Sarcomeric Alpha Actinin Recombinant Rabbit Monoclonal Antibody [JE45-22] (ET7109-42)

UNIPROT #

P35609

PROTEIN NAME

Sarcomeric Alpha Actinin

SYNONYMS

Actin binding protein antibody;Actinin alpha 2 antibody;ACTN 2 antibody;ACTN2 antibody;ACTN2_HUMAN antibody;Alpha actinin 2 antibody;Alpha actinin skeletal muscle antibody;Alpha actinin skeletal muscle isoform 2 antibody;Alpha-actinin skeletal muscle isoform 2 antibody;Alpha-actinin-2 antibody;CMD1AA antibody;F actin cross linking protein antibody;F-actin cross-linking protein antibody

SEQUENCE SIMILARITIES

Belongs to the alpha-actinin family.

TISSUE SPECIFICITY

Expressed in both skeletal and cardiac muscle.

POST-TRANSLATIONAL MODIFICATION

Ubiquitinated by FBXL22, leading to proteasomal degradation.

SUBCELLULAR LOCATION

Cytoplasm.

FUNCTION

Alpha-actinin-2 is a protein which in humans is encoded by the ACTN2 gene. This gene encodes an alpha-actinin isoform that is expressed in both skeletal and cardiac muscles and functions to anchor myofibrillar actin thin filaments and titin to Z-discs. The primary function of alpha-actinin-2 is to crosslink filamentous actin molecules and titin molecules from adjoining sarcomeres at Z-discs, a function that is modulated by phospholipids. It is clear from studies by Hampton et al. that this crosslinking can assume a variety of conformations, with preferences for 60° and 120° angles. Alpha-actinin-2 also functions in docking signalling molecules at Z-discs, and additional studies have also implicated alpha-actinin-2 in the binding of cardiac ion channels, Kv1.5 in particular.