SEC61A Recombinant Rabbit Monoclonal Antibody [JE35-35] (HA722450)

UNIPROT #

P61619

PROTEIN NAME

SEC61A

SYNONYMS

chunp6898 antibody;fb62c11 antibody;HSEC61 antibody;protein transport protein SEC61 alpha subunit antibody;protein transport protein Sec61 subunit alpha antibody;Protein transport protein Sec61 subunit alpha isoform 1 antibody;S61A1_HUMAN antibody;SEC 61 antibody;SEC 61A antibody;Sec61 alpha 1 antibody;Sec61 alpha 1 subunit antibody;Sec61 alpha 1 subunit (S. cerevisiae) antibody;Sec61 alpha-1 antibody;SEC61 antibody;Sec61 homolog antibody;SEC61A1 antibody;sec61aa antibody

SUBCELLULAR LOCATION

Endoplasmic reticulum membrane.

FUNCTION

Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across the endoplasmic reticulum (ER). Forms a ribosome receptor and a gated pore in the ER membrane, both functions required for cotranslational translocation of nascent polypeptides. May cooperate with auxiliary protein SEC62, SEC63 and HSPA5/BiP to enable post-translational transport of small presecretory proteins. The SEC61 channel is also involved in ER membrane insertion of transmembrane proteins: it mediates membrane insertion of the first few transmembrane segments of proteins, while insertion of subsequent transmembrane regions of multi-pass membrane proteins is mediated by the multi-pass translocon (MPT) complex. The SEC61 channel cooperates with the translocating protein TRAM1 to import nascent proteins into the ER. Controls the passive efflux of calcium ions from the ER lumen to the cytosol through SEC61 channel, contributing to the maintenance of cellular calcium homeostasis. Plays a critical role in nephrogenesis, specifically at pronephros stage.