SEC62 Recombinant Rabbit Monoclonal Antibody [JE62-80] (HA721534)

UNIPROT #

Q99442

PROTEIN NAME

SEC62

SYNONYMS

Dtrp1 antibody;FLJ32803 antibody;hTP-1 antibody;HTP1 antibody;Membrane protein SEC62, S.cerevisiae, homolog of antibody;OTTHUMP00000213390 antibody;sec62 antibody;SEC62 homolog (S. cerevisiae) antibody;SEC62_HUMAN antibody;TLOC1 antibody;TP-1 antibody;Translocation protein 1 antibody;Translocation protein sec62 antibody

SUBCELLULAR LOCATION

Endoplasmic reticulum membrane.

FUNCTION

The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. The protein encoded by this gene and SEC63 protein are found to be associated with ribosome-free SEC61 complex. It is speculated that Sec61-Sec62-Sec63 may perform post-translational protein translocation into the ER. The Sec61-Sec62-Sec63 complex might also perform the backward transport of ER proteins that are subject to the ubiquitin-proteasome-dependent degradation pathway. The encoded protein is an integral membrane protein located in the rough ER. Mediates post-translational transport of precursor polypeptides across endoplasmic reticulum (ER). Proposed to act as a targeting receptor for small presecretory proteins containing short and apolar signal peptides. Targets and properly positions newly synthesized presecretory proteins into the SEC61 channel-forming translocon complex, triggering channel opening for polypeptide translocation to the ER lumen.