Septin 2 Recombinant Rabbit Monoclonal Antibody [JB41-30] (ET7107-05)

UNIPROT #

Q15019

PROTEIN NAME

Septin 2

SYNONYMS

DIFF6 antibody;hNEDD5 antibody;KIAA0158 antibody;NEDD 5 antibody;NEDD5 antibody;Neural precursor cell expressed developmentally down regulated 5 antibody;Neural precursor cell expressed developmentally down regulated protein 5 antibody;Pnutl3 antibody;Protein NEDD5 antibody;SEPT2 antibody;septin 2 antibody

SEQUENCE SIMILARITIES

Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.

TISSUE SPECIFICITY

Widely expressed. Up-regulated in liver cancer.

SUBCELLULAR LOCATION

Cytoplasm. Cytoskeleton.

FUNCTION

Filament-forming cytoskeletal GTPase. Forms a filamentous structure with SEPT12, SEPT6, SEPT2 and probably SEPT4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation . Required for normal organization of the actin cytoskeleton. Plays a role in the biogenesis of polarized columnar-shaped epithelium by maintaining polyglutamylated microtubules, thus facilitating efficient vesicle transport, and by impeding MAP4 binding to tubulin. Required for the progression through mitosis. Forms a scaffold at the midplane of the mitotic splindle required to maintain CENPE localization at kinetochores and consequently chromosome congression. During anaphase, may be required for chromosome segregation and spindle elongation. Plays a role in ciliogenesis and collective cell movements. In cilia, required for the integrity of the diffusion barrier at the base of the primary cilium that prevents diffusion of transmembrane proteins between the cilia and plasma membranes: probably acts by regulating the assembly of the tectonic-like complex (also named B9 complex) by localizing TMEM231 protein.