Serotonin transporter Recombinant Rabbit Monoclonal Antibody [JE34-53] (HA721544)

UNIPROT #

P31645

PROTEIN NAME

Serotonin transporter

SYNONYMS

5 HTT antibody;5 HTTLPR antibody;5 hydroxytryptamine (serotonin) transporter antibody;5 hydroxytryptamine transporter antibody;5HT transporter antibody;5HTT antibody;hSERT antibody;HTT antibody;Na+/Cl- dependent serotonin transporter antibody;OCD1 antibody;SC6A4_HUMAN antibody;Serotonin transporter 1 antibody;SERT antibody;SERT1 antibody;Slc6a4 antibody;Sodium dependent serotonin transporter antibody;Sodium-dependent serotonin transporter antibody;Solute carrier family 6 (neurotransmitter transporter) member 4 antibody;solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 antibody;Solute carrier family 6 member 4 antibody

SUBCELLULAR LOCATION

Cell membrane. Endomembrane system. Endosome membrane. Translocates from intracellular locations to the plasma membrane. Density of transporter molecules on the plasma membrane is itself regulated by serotonin.

FUNCTION

The serotonin transporter (SERT or 5-HTT) also known as the sodium-dependent serotonin transporter and solute carrier family 6 member 4 is a protein that in humans is encoded by the SLC6A4 gene. SERT is a type of monoamine transporter protein that transports the neurotransmitter serotonin from the synaptic cleft back to the presynaptic neuron, in a process known as serotonin reuptake. This transport of serotonin by the SERT protein terminates the action of serotonin and recycles it in a sodium-dependent manner. Many antidepressant medications of the SSRI and tricyclic antidepressant classes work by binding to SERT and thus reducing serotonin reuptake. It is a member of the sodium:neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake and may play a role in sudden infant death syndrome, aggressive behavior in Alzheimer disease patients, post-traumatic stress disorder and depression-susceptibility in people experiencing emotional trauma.