SHP-1 Rabbit Polyclonal Antibody (ER1802-74)

UNIPROT #

P29350

PROTEIN NAME

SHP-1

SYNONYMS

70Z-SHP antibody;EC 3.1.3.48 antibody;HCP antibody;HCPH antibody;Hematopoietic cell phosphatase antibody;Hematopoietic cell protein tyrosine phosphatase antibody;Hematopoietic cell protein-tyrosine phosphatase antibody;HPTP1C antibody;Protein tyrosine phosphatase 1C antibody;Protein tyrosine phosphatase non receptor type 6 antibody;Protein tyrosine phosphatase SHP1 antibody;Protein-tyrosine phosphatase 1C antibody;protein-tyrosine phosphatase SHP 1 antibody;Protein-tyrosine phosphatase SHP-1 antibody;PTN6_HUMAN antibody;PTP 1C antibody;PTP-1C antibody;PTP1C antibody;Ptpn6 antibody;SH PTP 1 antibody;SH PTP1 antibody;SH-PTP1 antibody;SHP 1 antibody;SHP 1L antibody;SHP1 antibody;SHP1L antibody;tyrosine protein phosphatase non receptor type 6 antibody;Tyrosine-protein phosphatase non-receptor type 6 antibody

SEQUENCE SIMILARITIES

Belongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily.

TISSUE SPECIFICITY

Isoform 1 is expressed in hematopoietic cells. Isoform 2 is expressed in non-hematopoietic cells.

POST-TRANSLATIONAL MODIFICATION

Phosphorylated on tyrosine residues. Binding of KITLG/SCF to KIT increases tyrosine phosphorylation (By similarity). Phosphorylation at Tyr-564 enhances phosphatase activity.

SUBCELLULAR LOCATION

Nucleus. Cytoplasm.

FUNCTION

The steady state of protein tyrosyl phosphorylation in cells is regulated by the opposing action of tyrosine kinases and protein tyrosine phosphatases (PTPs). Several groups have independently identified a non-transmembrane PTP, designated SH-PTP1 (also known as PTP1C, HCP and SHP), which is primarily expressed in hematopoietic cells and characterized by the presence of two SH2 domains N-terminal to the PTP domain. SH2 domains generally mediate the association of regulatory molecules with specific phosphotyrosine-containing sites on autophosphorylated receptors, thereby controlling the initial interaction of receptors with these substrates. A second and much more widely expressed PTP with SH2 domains, SH-PTP2 (also designated PTP1D and Syp), has been identified. Strong sequence similarity between SH-PTP2 and the Drosophila gene corkscrew (CSW) and their similar patterns of expression suggest that SH-PTP2 is the human corkscrew homolog.