Sigma1-receptor Rabbit Polyclonal Antibody (HA500511)

UNIPROT #

Q99720

PROTEIN NAME

Sigma1-receptor

SYNONYMS

Aging associated gene 8 protein antibody;Aging-associated gene 8 protein antibody;AL024364 antibody;hSigmaR1 antibody;mSigmaR1 antibody;opioid receptor, sigma 1 antibody;opioid receptor, sigma 1 isoform 1 antibody;RP23 167I12.6 antibody;SGMR1_HUMAN antibody;SIG 1R antibody;SIG-1R antibody;Sigma 1-type opioid receptor antibody;Sigma non-opioid intracellular receptor 1 antibody;sigma1 receptor antibody;Sigma1-receptor antibody;Sigma1R antibody;Sigmar1 antibody;SR BP antibody;SR-BP antibody;SR31747 binding protein antibody;SR31747-binding protein antibody;SRBP antibody

SUBCELLULAR LOCATION

Cell junction, Cell membrane, Cell projection, Cytoplasmic vesicle, Endoplasmic reticulum, Lipid droplet, Membrane, Nucleus, Postsynaptic cell membrane, Synapse.

FUNCTION

This gene encodes a receptor protein that interacts with a variety of psychotomimetic drugs, including cocaine and amphetamines. The receptor is believed to play an important role in the cellular functions of various tissues associated with the endocrine, immune, and nervous systems. As indicated by its previous name, opioid receptor sigma 1 (OPRS1), the product of this gene was erroneously thought to function as an opioid receptor; it is now thought to be a non-opioid receptor. Mutations in this gene has been associated with juvenile amyotrophic lateral sclerosis 16. Alternative splicing of this gene results in transcript variants encoding distinct isoforms.