SIRT6 Rabbit Polyclonal Antibody (R1511-1)

UNIPROT #

Q8N6T7

PROTEIN NAME

SIRT6

SYNONYMS

2810449N18Rik antibody;AI043036 antibody;Mono ADP ribosyltransferase sirtuin 6 antibody;NAD-dependent protein deacetylase sirtuin-6 antibody;Regulatory protein SIR2 homolog 6 antibody;Regulatory protein SIR2 homolog antibody;SIR2 like 6 antibody;SIR2 like protein 6 antibody;Sir2 related protein type 6 antibody;SIR2-like protein 6 antibody;SIR2L6 antibody;SIR6_HUMAN antibody;SIRT 6 antibody;SIRT6 antibody;Sirtuin (silent mating type information regulation 2 homolog) 6 (S. cerevisiae) antibody;Sirtuin 6 antibody;Sirtuin type 6 antibody;Sirtuin6 antibody

SEQUENCE SIMILARITIES

Belongs to the sirtuin family. Class IV subfamily.

SUBCELLULAR LOCATION

Nucleus, cytoplasm

FUNCTION

The Silent Information Regulator (Sir2) family of genes is a highly conserved group of genes that encode nicotinamide adenine dinucleotide (NAD)-dependent protein deacetylases, also known as class III histone deacetylases. The first discovered and best characterized of this family is Saccharomyces cerevisiae Sir2, which is involved in silencing of mating type loci, telomere maintenance, DNA damage response, and cell aging. SirT6, a mammalian homolog of Sir2, is a nuclear, chromatin-associated protein that promotes the normal maintenance of genome integrity mediated by the base excision repair (BER) pathway. The BER pathway repairs single-stranded DNA lesions that arise spontaneously from endogenous alkylation, oxidation, and deamination events. SirT6 deficient mice show increased sensitivity to DNA-damaging agents, including the alkylating agents MMS and H2O2. In addition, these mice show genome instability with increased frequency of fragmented chromosomes, detached centromeres, and gaps. SirT6 may regulate the BER pathway by deacetylating DNA Polβ or other core components of the pathway.