Skp1 Recombinant Rabbit Monoclonal Antibody [JM27-37] (ET1705-43)

UNIPROT #

P63208

PROTEIN NAME

Skp1

SYNONYMS

Cyclin A/CDK2 associated p19 antibody;Cyclin A/CDK2 associated protein p19 antibody;Cyclin-A/CDK2-associated protein p19 antibody;EMC19 antibody;MGC34403 antibody;OCP 2 antibody;OCP II antibody;OCP II protein antibody;OCP-2 antibody;OCP-II antibody;OCP2 antibody;OCPII antibody;Organ of Corti protein 2 antibody;Organ of Corti protein II antibody;OTTHUMP00000159379 antibody;OTTHUMP00000159380 antibody;OTTHUMP00000228275 antibody;OTTHUMP00000228276 antibody;OTTHUMP00000228278 antibody;OTTHUMP00000228279 antibody;OTTHUMP00000228281 antibody;p19A antibody;p19skp1 antibody;RNA polymerase II elongation factor like protein antibody;RNA polymerase II elongation factor like protein OCP2 antibody;RNA polymerase II elongation factor-like protein antibody;S phase kinase associated protein 1 antibody;S phase kinase associated protein 1A antibody;S phase kinase associated protein 1A p19A antibody;S-phase kinase-associated protein 1 antibody;SIII antibody;Skp 1 antibody;SKP 1A antibody;skp1 antibody;SKP1_HUMAN antibody;SKP1A antibody;TCEB1L antibody;Transcription Elongation Factor B 1 like antibody;Transcription elongation factor B antibody;Transcription elongation factor B SIII polypeptide 1 like antibody

SEQUENCE SIMILARITIES

Belongs to the SKP1 family.

POST-TRANSLATIONAL MODIFICATION

Undergoes autophagy-mediated degradation in the liver in a time-dependent manner.

SUBCELLULAR LOCATION

Cytoplasm. Nucleus.

FUNCTION

S-phase kinase-associated protein 1 is an enzyme that in humans is encoded by the SKP1 gene. This gene encodes a protein that is a member of the SCF ubiquitin ligase protein complex. It binds to F-box proteins (proteins containing an F-box motif), such as cyclin F, S-phase kinase-associated protein 2, and other regulatory proteins involved in ubiquitin dependent proteolysis. The encoded protein also collaborates with a network of proteins to control beta-catenin levels and affects the activity level of beta-catenin dependent TCF transcription factors. Studies have also characterized the protein as an RNA polymerase II elongation factor. Alternative splicing of this gene results in two transcript variants. A related pseudogene has been identified on chromosome 7.