SLC45A3 Recombinant Rabbit Monoclonal Antibody [JE58-86] (HA721018)

UNIPROT #

Q96JT2

PROTEIN NAME

SLC45A3

SYNONYMS

IPCA 2 antibody;IPCA 8 antibody;IPCA6 antibody;PCANAP2 antibody;PCANAP6 antibody;PCANAP8 antibody;Prostate cancer associated gene 2 antibody;Prostate cancer associated gene 6 antibody;Prostate cancer associated gene 8 antibody;Prostate cancer associated protein 2 antibody;Prostate cancer associated protein 6 antibody;Prostate cancer associated protein 8 antibody;Prostate cancer-associated protein 6 antibody;Prostein antibody;PRST antibody;S45A3_HUMAN antibody;Slc45a3 antibody;Solute carrier family 45 member 3 antibody

SUBCELLULAR LOCATION

Membrane.

FUNCTION

Solute carrier family 45 member 3 (SLC45A3), also known as prostate cancer-associated protein 6 or prostein, is a protein that in humans is encoded by the SLC45A3 gene. SLC45A3 is an androgen-regulated gene and a prostate specific marker expressed in prostatic glandular cells. SLC45A3 is the second most common gene fusion partner in prostate cancers. SLC45A3-ERG and SLC45A3-ELK4 fusion transcripts have been detected in prostate cancer. Loss of prostein expression in SLC45A3-ERG tumors are significantly associated with high Gleason scores and poor clinical outcomes. Prostein immunoreactivity is seen in the majority of primary and metastatic prostate carcinomas. Staining for prostein in conjunction with PSA improves identification of prostatic origin in unknown primary lesions, when compared against prostein or PSA staining alone.