SNX1 Recombinant Rabbit Monoclonal Antibody [JG40-06] (ET7109-02)

UNIPROT #

Q13596

PROTEIN NAME

SNX1

SYNONYMS

HsT17379 antibody;MGC8664 antibody;SNX 1 antibody;SNX 1a antibody;Snx1 antibody;SNX1_HUMAN antibody;SNX1A antibody;Sorting nexin 1 antibody;Sorting nexin 1A antibody;Sorting nexin-1 antibody;Vps5 antibody

SEQUENCE SIMILARITIES

Belongs to the sorting nexin family.

SUBCELLULAR LOCATION

Endosome. Golgi apparatus.

FUNCTION

Sorting nexin 1 (SNX1) is a member of a large family of hydrophilic proteins that interact with a variety of receptor types and are involved in intracellular trafficking. SNX1 and the related splice variant, SNX1A, bind the epidermal growth factor (EGF) receptor, facilitate its transport to lysosome, and thereby contribute to the degradation of the receptor. SNX2 and SNX4 share a high degree of amino acid similarity with SNX1, as they all contain a characteristic phox homology (PX) domain. These proteins are all partially associated with cellular membranes, and they, likewise, associate with EGF, PDGF and insulin receptor tyrosine kinases. These nexins are widely expressed and yet have various tissue distribution patterns. Additionally, the sorting nexins can associate with each other and with a variety of other cellular proteins, suggesting that they exist as part of multisubunit complexes. The related protein, SNX3, comprises a distinct subgroup of nexins that share less sequence similarity outside of the PX domain and have dramatically different binding affinities for the tyrosine kinase receptors.