SPAK Recombinant Rabbit Monoclonal Antibody [JE53-64] (ET7110-37)

UNIPROT #

Q9UEW8

PROTEIN NAME

SPAK

SYNONYMS

DCHT antibody;DKFZp686K05124 antibody;OTTHUMP00000165175 antibody;PASK antibody;Proline alanine rich STE20 related kinase antibody;Serine threonine kinase 39 (STE20/SPS1 homolog yeast) antibody;Serine threonine kinase 39 antibody;Serine/threonine protein kinase 39 antibody;Serine/threonine-protein kinase 39 antibody;Small intestine SPAK like kinase antibody;SPAK antibody;Ste 20 related kinase antibody;Ste-20-related kinase antibody;Ste20 like protein kinase antibody;STE20/SPS1 homolog antibody;STE20/SPS1 related proline alanine rich protein kinase antibody;STE20/SPS1-related proline-alanine-rich protein kinase antibody;STK 39 antibody;Stk39 antibody;STK39_HUMAN antibody

SEQUENCE SIMILARITIES

Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.

TISSUE SPECIFICITY

Predominantly expressed in brain and pancreas followed by heart, lung, kidney, skeletal muscle, liver, placenta and testis.

POST-TRANSLATIONAL MODIFICATION

Phosphorylated at Ser-309 by PRKCQ. Autophosphorylation at Thr-231 positively regulates its activity (By similarity).

SUBCELLULAR LOCATION

Nucleus, cytoplasm.

FUNCTION

STE20/SPS1-related proline-alanine-rich protein kinase is an enzyme that in humans is encoded by the STK39 gene. This gene encodes a serine/threonine kinase that is thought to function in the cellular stress response pathway. The kinase is activated in response to hypotonic stress, leading to phosphorylation of several cation-chloride-coupled cotransporters. The catalytically active kinase specifically activates the p38 MAP kinase pathway, and its interaction with p38 decreases upon cellular stress, suggesting that this kinase may serve as an intermediate in the response to cellular stress. Some studies suggest that this gene might be linked to high blood pressure.