SRD5A2 Recombinant Rabbit Monoclonal Antibody [JE39-31] (HA722343)

UNIPROT #

P31213

PROTEIN NAME

SRD5A2

SYNONYMS

3 oxo 5 alpha steroid 4 dehydrogenase 2 antibody;3-oxo-5-alpha-steroid 4-dehydrogenase 2 antibody;5 alpha SR2 antibody;5 alpha-SR2 antibody;5ART2 antibody;e II 5 alpha reductase antibody;EC antibody;MGC138457 antibody;Micropenis, included antibody;S5A2_HUMAN antibody;S5AR 2 antibody;SR type 2 antibody;SRD5A2 antibody;Steroid 5 alpha reductase 2 antibody;Steroid 5-alpha-reductase 2 antibody;Steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) antibody;Type II 5-alpha reductase antibody

SUBCELLULAR LOCATION

Microsome membrane, Endoplasmic reticulum membrane.

FUNCTION

The human gene SRD5A2 encodes the 3-oxo-5α-steroid 4-dehydrogenase 2 enzyme, also known as 5α-reductase type 2 (5αR2), one of three isozymes of 5α-reductase. 5αR2 catalyzes the conversion of the male sex hormone testosterone into the more potent androgen, dihydrotestosterone. 5αR2 is a microsomal protein expressed at high levels in androgen-sensitive tissues such as the prostate. The enzyme is active at acidic pH and is sensitive to the 4-azasteroid inhibitor finasteride. Deficiencies in 5αR2 activity of the can lead to a condition known as 5α-reductase 2 deficiency, which is a cause of 46,XY DSD that presents as atypical male genitalia.