STAT6 Recombinant Rabbit Monoclonal Antibody [SY02-72] (ET1607-61)

UNIPROT #

P42226

PROTEIN NAME

STAT6

SYNONYMS

12S1644 antibody;D12S1644 antibody;IL 4 STAT antibody;IL-4 Stat antibody;IL4 STAT antibody;Interleukin 4 Induced antibody;Interleukin 4 Induced Transcription Factor IL4 STAT antibody;Signal transducer and activator of transcription 6 antibody;Signal Transducer And Activator Of Transcription 6 Interleukin 4 Induced antibody;Signal Transducer And Activator Of Transcription 6 Nirs Variant 1 antibody;Signal transducer and activator of transcription 6, interleukin 4 induced antibody;STAT 6 antibody;STAT interleukin4 induced antibody;STAT, interleukin4 induced antibody;Stat6 antibody;STAT6_HUMAN antibody;STAT6B antibody;STAT6C antibody;Transcription factor IL 4 STAT antibody

SEQUENCE SIMILARITIES

Belongs to the transcription factor STAT family.

POST-TRANSLATIONAL MODIFICATION

Tyrosine phosphorylated on Tyr-641 following stimulation by IL4/interleukin-4. Tyrosine phosphorylated following stimulation by IL3/interleukin-3 (By similarity). Dephosphorylation on tyrosine residues by PTPN2 negatively regulates the IL4/interleukin-4 mediated signaling.; Mono-ADP-ribosylated by PARP14.

SUBCELLULAR LOCATION

Cytoplasm, Nucleus.

FUNCTION

Signal transducer and activator of transcription 6 (STAT6) is a transcription factor that belongs to the Signal Transducer and Activator of Transcription (STAT) family of proteins. The proteins of STAT family transmit signals from a receptor complex to the nucleus and activate gene expression. Similarly as other STAT family proteins, STAT6 is also activated by growth factors and cytokines. STAT6 is mainly activated by cytokines interleukin-4 and interleukin-13. STAT6-mediated signaling pathway is required for the development of T-helper type 2 (Th2) cells and Th2 immune response. Activation of STAT6 signaling pathway is necessary in macrophage function, and is required for the M2 subtype activation of macrophages. STAT6 is also involved in IL4 signaling in B cells, and STAT6 determines the levels of CD20 on the surface of normal and malignant B lymphocytes. STAT6 also plays a critical role in Th2 lung inflammatory responses including clearance of parasitic infections and in the pathogenesis of asthma. Th2-cell derived cytokines as IL-4 and IL-13 induce the production of IgE which is a major mediator in allergic response.