Sumo 2+3 Recombinant Rabbit Monoclonal Antibody [JJ087-04] (ET1701-17)

UNIPROT #

P55854

PROTEIN NAME

Sumo 2+3

SYNONYMS

HSMT3 antibody;MGC117191 antibody;OTTHUMP00000115275 antibody;OTTHUMP00000115276 antibody;OTTHUMP00000115277 antibody;Sentrin 2 antibody;Small ubiquitin like modifier 2 antibody;Small ubiquitin related modifier 2 antibody;small ubiquitin-like modifier 3 antibody;small ubiquitin-related modifier 3 antibody;SMT3 homolog 1 antibody;SMT3 homolog 2 antibody;SMT3 suppressor of mif two 3 homolog 1 antibody;SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae) antibody;SMT3 suppressor of mif two 3 homolog 2 antibody;SMT3 suppressor of mif two 3 homolog 3 (S. cerevisiae) antibody;SMT3 suppressor of mif two 3 homolog 3 antibody;SMT3A antibody;SMT3B antibody;SMT3H1 antibody;SMT3H2 antibody;Sumo2 antibody;Sumo3 antibody;Ubiquitin like protein SMT3A antibody;Ubiquitin like protein SMT3B antibody

SEQUENCE SIMILARITIES

Belongs to the ubiquitin family. SUMO subfamily.

TISSUE SPECIFICITY

Expressed predominantly in liver.

POST-TRANSLATIONAL MODIFICATION

Polymeric chains can be formed through Lys-11 cross-linking.; Cleavage of precursor form by SENP1, SENP2 or SENP5 is necessary for function.

SUBCELLULAR LOCATION

Cytoplasm, Nucleus.

FUNCTION

The small ubiquitin-related modifier (SUMO) proteins, which include SUMO-1, SUMO-2 and SUMO-3, belong to the ubiquitin-like protein family. Like ubiquitin, the SUMO proteins are synthesized as precursor proteins that undergo processing before conjugation to target proteins. Also, both utilize the E1, E2, and E3 cascade enzymes for conjugation. However, SUMO and ubiquitin differ with respect to targeting. Ubiquitination predominantly targets proteins for degradation, whereas sumoylation targets proteins to a variety of cellular processing, including nuclear transport, transcriptional regulation, apoptosis and protein stability. The unconjugated SUMO-1, SUMO-2 and SUMO-3 proteins localize to the nuclear membrane, nuclear bodies and cytoplasm, respectively. SUMO-1 utilizes Ubc9 for conjugation to several target proteins, which include IkBa, MDM2, p53, PML and Ran GAP1. SUMO-2 and SUMO-3 contribute to a greater percentage of protein modification than does SUMO-1, and unlike SUMO-1, they can form polymeric chains. In addition, SUMO-3 regulates b-Amyloid generation and may be critical in the onset or progression of Alzheimer's disease.