TAF1 Recombinant Rabbit Monoclonal Antibody [JE40-02] (HA722747)

UNIPROT #

P21675

PROTEIN NAME

TAF1

SYNONYMS

BA2R antibody;CCG 1 antibody;CCG1 antibody;CCGS antibody;Cell cycle G1 phase defect antibody;Cell cycle gene 1 protein antibody;Complementation of cell cycle block G1 to S antibody;DYT3 protein antibody;NSCL 2 antibody;NSCL2 antibody;OF antibody;p250 antibody;TAF 1 antibody;TAF(II)250 antibody;TAF1 RNA polymerase II antibody;TAF130 antibody;TAF145 antibody;TAF2A antibody;TAFII 250 antibody;TAFII250 antibody;TATA box binding protein (TBP) associated factor RNA polymerase II A 250kD antibody;TATA box binding protein (TBP)-associated factor antibody;TBP associated factor 1 antibody;TBP associated factor 145 kDa antibody;TBP associated factor 250 kDa antibody;Transcription factor TFIID p250 polypeptide antibody;Transcription initiation factor TFIID 250 kDa subunit antibody;Transcription initiation factor TFIID subunit 1 antibody;YGR274C antibody

SUBCELLULAR LOCATION

Nucleus.

FUNCTION

The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription. TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. TAF1 is the largest component and core scaffold of the TFIID complex, involved in nucleating complex assembly. TAF1 forms a promoter DNA binding subcomplex of TFIID, together with TAF7 and TAF2. Contains novel N- and C-terminal Ser/Thr kinase domains which can autophosphorylate or transphosphorylate other transcription factors. Phosphorylates TP53 on 'Thr-55' which leads to MDM2-mediated degradation of TP53. Phosphorylates GTF2A1 and GTF2F1 on Ser residues. Possesses DNA-binding activity. Essential for progression of the G1 phase of the cell cycle. Exhibits histone acetyltransferase activity towards histones H3 and H4.