TAF15 Recombinant Rabbit Monoclonal Antibody [JE61-92] (HA720098)

UNIPROT #

Q92804

PROTEIN NAME

TAF15

SYNONYMS

68 kDa TATA-binding protein-associated factor antibody;Npl3 antibody;RBP56 antibody;RBP56_HUMAN antibody;RNA binding protein 56 antibody;RNA-binding protein 56 antibody;TAF antibody;TAF(II)68 antibody;TAF15 antibody;TAF15 RNA polymerase II TATA box binding protein (TBP) associated factor 68kDa antibody;TAF2N antibody;TAFII68 antibody;TATA-binding protein-associated factor 2N antibody

SUBCELLULAR LOCATION

Nucleus, Cytoplasm.

FUNCTION

TATA-binding protein-associated factor 2N is a protein that in humans is encoded by the TAF15 gene. Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes a subunit of TFIID present in a subset of TFIID complexes. Translocations involving chromosome 17 and chromosome 9, where the gene for the nuclear receptor CSMF is located, result in a gene fusion product that is an RNA binding protein associated with a subset of extraskeletal myxoid chondrosarcomas. Two transcripts encoding different isoforms have been identified.