TBP-1 Rabbit Polyclonal Antibody (HA500413)

UNIPROT #

P17980

PROTEIN NAME

TBP-1

SYNONYMS

26S protease regulatory subunit 6A antibody;26S proteasome AAA-ATPase subunit RPT5 antibody;Human immunodeficiency virus tat transactivator binding protein 1 antibody;MGC8487 antibody;Proteasome (prosome macropain) 26S subunit ATPase 3 antibody;Proteasome 26S ATPase subunit 3 antibody;Proteasome 26S subunit ATPase 3 antibody;Proteasome subunit P50 antibody;PRS6A_HUMAN antibody;PSMC 3 antibody;PSMC3 antibody;Tat binding protein 1 antibody;TAT-binding protein 1 antibody;TBP-1 antibody;TBP1 antibody

SUBCELLULAR LOCATION

Cytoplasm, Nucleus.

FUNCTION

Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC3 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides. Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits, a base containing 6 ATPases including PSMC3 and few additional components.