Tbp7 Recombinant Rabbit Monoclonal Antibody [JE62-72] (HA721435)

UNIPROT #

P43686

PROTEIN NAME

Tbp7

SYNONYMS

26S protease regulatory subunit 6B antibody;26S proteasome AAA ATPase subunit RPT3 antibody;26S proteasome AAA-ATPase subunit RPT3 antibody;MB67 interacting protein antibody;MB67-interacting protein antibody;MIP224 antibody;Protease 26S subunit 6 antibody;Proteasome (prosome macropain) 26S subunit ATPase 4 antibody;Proteasome 19S S6 antibody;Proteasome 26S subunit ATPase 4 antibody;Proteasome 26S subunit, ATPase, 4 antibody;PRS6B_HUMAN antibody;PSMC4 antibody;RPT3 antibody;S6 antibody;Tat binding protein 7 antibody;TAT-binding protein 7 antibody;TBP 7 antibody;TBP-7 antibody

SUBCELLULAR LOCATION

Cytoplasm, Nucleus.

FUNCTION

26S protease regulatory subunit 6B, also known as 26S proteasome AAA-ATPase subunit Rpt3, is an enzyme that in humans is encoded by the PSMC4 gene. This protein is one of the 19 essential subunits of a complete assembled 19S proteasome complex Six 26S proteasome AAA-ATPase subunits (Rpt1, Rpt2, Rpt3 (this protein), Rpt4, Rpt5, and Rpt6) together with four non-ATPase subunits (Rpn1, Rpn2, Rpn10, and Rpn13) form the base sub complex of 19S regulatory particle for proteasome complex. The gene PSMC4 encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. This subunit has been shown to interact with an orphan member of the nuclear hormone receptor superfamily highly expressed in liver, and with gankyrin, a liver oncoprotein. Two transcript variants encoding different isoforms have been identified. The human PSMC3 gene has 11 exons and locates at chromosome band 19q13.11-q13.13. The human protein 26S protease regulatory subunit 6B is 47kDa in size and composed of 418 amino acids. The calculated theoretical pI of this protein is 5.09.