TCP1 alpha/CCTA Recombinant Rabbit Monoclonal Antibody [JE48-48] (ET7109-79)

UNIPROT #

P17987

PROTEIN NAME

TCP1 alpha/CCTA

SYNONYMS

AI528772 antibody;c-cpn antibody;CCT alpha antibody;CCT antibody;CCT-alpha antibody;CCT1 antibody;Ccta antibody;CCTalpha antibody;D6S230E antibody;MGC133746 antibody;p63 antibody;T complex 1 antibody;T complex protein 1 alpha subunit antibody;T complex protein 1 antibody;T-complex homolog TCP1 antibody;T-complex protein 1 subunit alpha antibody;T-complex protein 1 subunit alpha B antibody;Tailless complex polypeptide 1 antibody;Tailless complex polypeptide 1A antibody;Tailless complex polypeptide 1B antibody;TCP 1 alpha antibody;Tcp-1 antibody;TCP-1-alpha antibody;TCP1 antibody;TCPA_HUMAN antibody;Tp63 antibody;TRic antibody

SEQUENCE SIMILARITIES

Belongs to the TCP-1 chaperonin family.

SUBCELLULAR LOCATION

Cytoplasm. Cytoskeleton.

FUNCTION

The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized. In addition, three pseudogenes that appear to be derived from this gene have been found. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin (Probable).