TESPA1 Rabbit Polyclonal Antibody (R1309-16)
Catalog# R1309-16
Rabbit Polyclonal to TESPA1
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WB
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IF-Cell
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IHC-P
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FC
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Human
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Mouse
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Rat
Specifications
Product Type
Rabbit polyclonal primary
Product Name
TESPA1 Rabbit Polyclonal Antibody (R1309-16)
Immunogen
Synthetic peptide within human tespa1 aa 221-270 / 521 (f249e).
Host
Rabbit
Positive Control
Human thymus tissue lysate, mouse thymus tissue lysate, human liver tissue lysate, A431 cell lysate, A172, rat brain, human lung cancer, mouse brain, HepG2.
Conjugation
Unconjugated
Clonality
Polyclonal
RRID
APPLICATION DILUTION
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WB
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1:500-1:1,000
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IF-Cell
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1:200
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IHC-P
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1:50
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FC
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1:50-1:100
PROPERTIES
Form
Liquid
Storage Condition
Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.
Storage Buffer
1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1ug/ul
Purification
Immunogen affinity purified.
Molecular Weight
Predicted band size: 59 kDa
Isotype
IgG
TARGET
UNIPROT #
PROTEIN NAME
TESPA1
SYNONYMS
HSPC257 antibody;K0748_HUMAN antibody;KIAA0748 antibody;Protein TESPA1 antibody;TESPA1 – thymocyte expressed, positive selection associated 1 antibody;TESPA1 antibody;thymocyte expressed, positive selection associated 1 antibody;Uncharacterized protein KIAA0748 antibody
POST-TRANSLATIONAL MODIFICATION
May be phosphorylated in response to store-operated Ca(+2) entry.
SUBCELLULAR LOCATION
Cytoplasm. Membrane, Endoplasmic reticulum, Signalosome.
FUNCTION
TESPA1 (Thymocyte-expressed positive selection-associated protein 1) is required for the development and maturation of T-cells, its function being essential for the late stages of thymocyte development. It plays a role in T-cell antigen receptor (TCR)-mediated activation of the ERK and NFAT signaling pathways, possibly by serving as a scaffolding protein that promotes the assembly of the LAT signalosome in thymocytes.
CITATIONS
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Songquan Wu
Tespa1 plays a role in the modulation of airway hyperreactivity through the IL-4/STAT6 pathway
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IF
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human
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Citation
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