TFCP2L1 Rabbit Polyclonal Antibody (R1307-8)

UNIPROT #

Q9NZI6

PROTEIN NAME

TFCP2L1

SYNONYMS

CP2 related transcriptional repressor 1 antibody;CP2-related transcriptional repressor 1 antibody;CRTR 1 antibody;CRTR-1 antibody;LBP 9 antibody;LBP9 antibody;TF2L1_HUMAN antibody;TFCP2 L1 antibody;TFCP2L1 antibody;Transcription factor CP2 like 1 antibody;Transcription factor CP2 like protein 1 antibody;Transcription factor CP2-like protein 1 antibody;Transcription factor LBP 9 antibody;Transcription factor LBP-9 antibody;Transcription factor LBP9 antibody

SEQUENCE SIMILARITIES

Belongs to the grh/CP2 family. CP2 subfamily.

TISSUE SPECIFICITY

Highly expressed in placental JEG-3 cells and very low levels of expression in non-steroidogenic cells. No expression was seen in adrenal NCI-H295A cells or in adrenal tissue.

SUBCELLULAR LOCATION

Nucleus.

FUNCTION

Transcription factor that facilitates establishment and maintenance of pluripotency in embryonic stem cells (ESCs). With KLF2, acts as the major effector of self-renewal that mediates induction of pluripotency downstream of LIF/STAT3 and Wnt/beta-catenin signaling. Required for normal duct development in the salivary gland and kidney. Coordinates the development of the kidney collecting ducts intercalated (IC) and principal (PC) cells, which regulate acid-base and salt-water homeostasis, respectively. Regulates the expression of IC genes including subunits B1 and D2 of the V-ATPase complex, OXGR1, CA12, SLC4A1, AQP6 and IC-specific transcription factor FOXI1. Regulates also the expression of JAG1 and subsequent notch signaling in the collecting duct. JAG1 initiates notch signaling in PCs but inhibits notch signaling in ICs. Acts as a transcriptional suppressor that may suppress UBP1-mediated transcriptional activation. Modulates the placental expression of CYP11A1.