TFE3 Recombinant Rabbit Monoclonal Antibody [JE60-60] (HA721896)

UNIPROT #

P19532

PROTEIN NAME

TFE3

SYNONYMS

bHLH e33 antibody;bHLHe33 antibody;Class E basic helix-loop-helix protein 33 antibody;RCCP 2 antibody;RCCP2 antibody;RCCX1 antibody;Renal cell carcinoma, papillary antibody;Tcfe 3 antibody;Tcfe3 antibody;TFE 3 antibody;Tfe3 antibody;TFE3_HUMAN antibody;TFEA antibody;Transcription factor binding to IGHM enhancer 3 antibody;Transcription factor E family, member A antibody;Transcription factor E3 antibody;Transcription factor for IgH enhancer antibody;Transcription factor for immunoglobulin heavy chain enhancer 3 antibody

SUBCELLULAR LOCATION

Cytoplasm, Nucleus.

FUNCTION

Transcription factor that acts as a master regulator of lysosomal biogenesis and immune response. Specifically recognizes and binds E-box sequences (5'-CANNTG-3'); efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFEB or MITF. Involved in the cellular response to amino acid availability by acting downstream of MTOR: in the presence of nutrients, TFE3 phosphorylation by MTOR promotes its cytosolic retention and subsequent inactivation. Upon starvation or lysosomal stress, inhibition of MTOR induces TFE3 dephosphorylation, resulting in nuclear localization and transcription factor activity. Maintains the pluripotent state of embryonic stem cells by promoting the expression of genes such as ESRRB; mTOR-dependent TFE3 cytosolic retention and inactivation promotes exit from pluripotency. Required to maintain the naive pluripotent state of hematopoietic stem cell; mTOR-dependent cytoplasmic retention of TFE3 promotes the exit of hematopoietic stem cell from pluripotency. Acts as a positive regulator of browning of adipose tissue by promoting expression of target genes; mTOR-dependent phosphorylation promotes cytoplasmic retention of TFE3 and inhibits browning of adipose tissue.