TIA1 Recombinant Rabbit Monoclonal Antibody [JM42-11] (ET1703-59)

UNIPROT #

P31483

PROTEIN NAME

TIA1

SYNONYMS

Cytotoxic granule associated RNA binding protein 1 antibody;Cytotoxic granule associated RNA binding protein antibody;mTIA-1 antibody;Nucleolysin TIA 1 isoform p40 antibody;Nucleolysin TIA-1 isoform p40 antibody;Nucleolysin TIA1 isoform p40 antibody;p40 TIA 1 antibody;p40-TIA-1 (containing p15-TIA-1) antibody;p40-TIA-1 antibody;RNA binding protein TIA 1 antibody;RNA binding protein TIA1 antibody;RNA-binding protein TIA-1 antibody;T-cell-restricted intracellular antigen-1 antibody;TIA 1 antibody;TIA 1 cytotoxic granule associated RNA binding protein antibody;Tia antibody;TIA-1 antibody;TIA1 antibody;TIA1 cytotoxic granule associated RNA binding protein antibody;TIA1 cytotoxic granule associated RNA binding protein like 1 antibody;TIA1 protein antibody;TIA1_HUMAN antibody;TIAL1 antibody;TIAR antibody;WDM antibody

SUBCELLULAR LOCATION

Nucleus, Cytoplasm, Stress granule.

FUNCTION

FAS, also referred to as CD95 or APO-1, is a type I transmembrane protein that plays a central role mediating viral immunity. TIA-1 and TIAR are two closely related proteins that possess three RRMs (RNA recognition motifs), designated RRM 1, 2 and 3. Although both TIA-1 and TIAR are thought to function as mediators of apoptotic cell death, their specific roles in such pathways are unknown. Unlike TIA-1, which is found in the granules of cytotoxic lymphocytes, TIAR expression is limited to the nucleus and found in a much broader range of cells including, but not limited to, cells of hematopoietic origin. TIAR is translocated to the cytoplasm shortly after FAS ligation and this event immediately proceeds the onset of DNA fragmentation. A novel serine/threonine kinase that is activated as a result of FAS ligation, designated FAST (FAS-activated serine/threonine), shows kinase specificity towards both TIA-1 and TIAR. In unstimulated Jurkat cells, FAST resides in the cytoplasm as a highly phosphorylated protein and is quickly dephosphorylated and activated in response to stimulated FAS.