TNFSF14 Rabbit Polyclonal Antibody (HA500384)

UNIPROT #

O43557

PROTEIN NAME

TNFSF14

SYNONYMS

CD 258 antibody;CD258 antibody;CD258 antigen antibody;Delta transmembrane LIGHT antibody;Herpes virus entry mediator ligand antibody;Herpesvirus entry mediator A antibody;Herpesvirus entry mediator ligand antibody;herpesvirus entry mediator-ligand antibody;HVEM L antibody;HVEM-L antibody;HVEML antibody;Ligand for herpesvirus entry mediator antibody;LIGHT antibody;LTg antibody;soluble form antibody;TNF14 antibody;TNF14_HUMAN antibody;TNFSF 14 antibody;Tnfsf14 antibody;TNFSF14 protein antibody;TR 2 antibody;TR2 antibody;Tumor necrosis factor (ligand) superfamily, member 14 antibody;Tumor necrosis factor ligand superfamily member 14 antibody;Tumor necrosis factor ligand superfamily, member 14 antibody;Tumor necrosis factor receptor like 2 antibody;tumor necrosis factor receptor-like 2 antibody;Tumor necrosis factor superfamily member 14 antibody;Tumor necrosis factor superfamily member LIGHT antibody

SUBCELLULAR LOCATION

Cell membrane, Secreted, Cytoplasm.

FUNCTION

LIGHT, also known as tumor necrosis factor superfamily member 14 (TNFSF14), is a secreted protein of the TNF superfamily. It is recognized by herpesvirus entry mediator (HVEM), as well as decoy receptor 3. The protein encoded by this gene is a member of the tumor necrosis factor (TNF) ligand family. This protein is a ligand for TNFRSF14, which is a member of the tumor necrosis factor receptor superfamily, and which is also known as a herpesvirus entry mediator (HVEM). Two alternatively spliced transcript variant encoding distinct isoforms have been reported. This protein may function as a costimulatory factor for the activation of lymphoid cells and as a deterrent to infection by herpesvirus. This protein has been shown to stimulate the proliferation of T cells, trigger apoptosis of various tumor cells and play a role in vascular normalisation processes. This protein is also reported to prevent tumor necrosis factor alpha-mediated apoptosis in primary hepatocytes. Similar to how CD4 is the primary mediating receptor in HIV infection, the HSV glycoprotein (gD) binds to the HVEM receptor which is demanded by TNFSF14/LIGHT lowering the ability for LIGHT to activate the NFκB pathway. NFκB is a survival factor helping to inhibit apoptosis which triggers a pathway inhibiting caspase 8. When gD from HSV binds to HVEM, LIGHT is non-competitively inhibited from binding, encouraging apoptosis in the infected cell.