Cardiac Troponin T Mouse Monoclonal Antibody [5-C7] (M1302-1)

UNIPROT #

P45379

PROTEIN NAME

Cardiac Troponin T

SYNONYMS

Cardiac muscle troponin T antibody;Cardiomyopathy dilated 1D (autosomal dominant) antibody;Cardiomyopathy hypertrophic 2 antibody;CMD1D antibody;CMH2 antibody;CMPD2 antibody;cTnT antibody;LVNC6 antibody;MGC3889 antibody;OTTHUMP00000033864 antibody;OTTHUMP00000033865 antibody;OTTHUMP00000033866 antibody;OTTHUMP00000033867 antibody;OTTHUMP00000033870 antibody;OTTHUMP00000218095 antibody;RCM3 antibody;TNNT 2 antibody;TNNT2 antibody;TNNT2_HUMAN antibody;TnTc antibody;Troponin T cardiac muscle antibody;Troponin T type 2 (cardiac) antibody;Troponin T type 2 cardiac antibody;Troponin T, cardiac muscle antibody;Troponin T2 cardiac antibody

SEQUENCE SIMILARITIES

Belongs to the troponin T family.

TISSUE SPECIFICITY

Heart. The fetal heart shows a greater expression in the atrium than in the ventricle, while the adult heart shows a greater expression in the ventricle than in the atrium. Isoform 6 predominates in normal adult heart. Isoforms 1, 7 and 8 are expressed in fetal heart. Isoform 7 is also expressed in failing adult heart.

POST-TRANSLATIONAL MODIFICATION

Phosphorylation at Thr-213 by PRKCA induces significant reduction in myofilament calcium sensitivity and actomyosin ATPase activity.

SUBCELLULAR LOCATION

Cytosol.

FUNCTION

Troponin, working in conjunction with tropomyosin, functions as a molecular switch, regulating muscle contraction in response to changes in the intracellular Ca2+ concentration. Troponin consists of three subunits: the Ca2+-binding subunit troponin C (TnC), the tropomyosin-binding subunit troponin T (TnT), and the inhibitory subunit troponin I (TnI).Troponin T type 2 (cTnT,TNNT2) is a cardiac troponin T isoform expressed in the human heart, that is essential for calcium-regulated myofibrillar ATPase activity. Assays for measuring serum concentrations of cTnT, as well as cTnI, have been reported for analyzing cardiac injury.