TRIF Recombinant Rabbit Monoclonal Antibody [PSH05-39] (HA722268)

UNIPROT #

Q8IUC6

PROTEIN NAME

TRIF

SYNONYMS

IIAE6 antibody;MGC35334 antibody;MyD88 3 antibody;Proline rich vinculin and TIR domain containing protein B antibody;Proline-rich antibody;PRVTIRB antibody;Putative NF kappa B activating protein 502H antibody;Putative NF-kappa-B-activating protein 502H antibody;Putative NFkB activating protein antibody;TCAM1_HUMAN antibody;TICAM 1 antibody;TICAM-1 antibody;Ticam1 antibody;TIR domain containing adapter molecule 1 antibody;TIR domain containing adapter protein inducing IFN beta antibody;TIR domain containing adaptor inducing interferon beta antibody;TIR domain-containing adapter molecule 1 antibody;TIR domain-containing adapter protein inducing IFN-beta antibody;Toll interleukin 1 receptor domain containing adapter protein inducing interferon beta antibody;Toll like receptor adaptor molecule 1 antibody;Toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta antibody;TRIF antibody;TRIF protein antibody;vinculin and TIR domain-containing protein B antibody

SUBCELLULAR LOCATION

Cytoplasmic vesicle, autophagosome, Cytoplasm, cytosol, Mitochondrion.

FUNCTION

TIR domain containing adaptor molecule 1 (TICAM1; formerly known as TIR-domain-containing adapter-inducing interferon-β or TRIF) is an adapter in responding to activation of toll-like receptors (TLRs). It mediates the rather delayed cascade of two TLR-associated signaling cascades, where the other one is dependent upon a MyD88 adapter. Toll-like receptors (TLRs) recognize specific components of microbial invaders and activate an immune response to these pathogens. After these receptors recognize highly conserved pathogenic patterns, a downstream signaling cascade is activated in order to stimulate the release of inflammatory cytokines and chemokines as well as to upregulate the expression of immune cells. All TLRs have a TIR domain that initiates the signaling cascade through TIR adapters. Adapters are platforms that organize downstream signaling cascades leading to a specific cellular response after exposure to a given pathogen.