Tryptophan Hydroxylase 1 (TPH1) Recombinant Rabbit Monoclonal Antibody [SC53-07] (ET1610-37)

UNIPROT #

P17752

PROTEIN NAME

Tryptophan Hydroxylase 1 (TPH1)

SYNONYMS

Indoleacetic acid 5 hydroxylase antibody;L tryptophan hydroxylase antibody;MGC119994 antibody;TPH 1 antibody;TPH antibody;TPH1 antibody;TPH1_HUMAN antibody;TPRH antibody;TRPH antibody;Tryptophan 5 hydroxylase 1 antibody;Tryptophan 5 monooxygenase 1 antibody;Tryptophan 5 monooxygenase antibody;Tryptophan 5-hydroxylase 1 antibody;Tryptophan 5-monooxygenase 1 antibody;Tryptophan hydroxylase 1 antibody

SEQUENCE SIMILARITIES

Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.

TISSUE SPECIFICITY

Isoform 2 seems to be less widely expressed than isoform 1.

SUBCELLULAR LOCATION

Cytosol, neuron projection.

FUNCTION

Phenylalanine hydroxylase (PAH), tyrosine hydroxylase (TH) and tryptophan hydroxylase (TPH) comprise a small family of monooxygenases that use tetrahydropterine as a cofactor during the catabolism of aromatic L-amino acids. PAH, TH and TPH all contain catalytic domains with an amino-terminal regulatory domain and a short carboxy-terminal tetramerization domain. Each of these enzymes also contains a single ferrous iron atom, which is bound to two histidines and a glutamate and is likely to be involved in the formation of the hydroxylating intermediate. TPH is the first and rate-limiting step in the biosynthesis of serotonin in the central nervous system and melatonin in the pineal gland. Alteration of TPH function may be a key factor in the pathology of several neuropsychiatric disorders associated with serotonin, including depression, aggression, alcoholism and schizophrenia. For instance, L-DOPA, which is used as a common therapy for Parkinson’s disease (PD) patients, inhibits TPH function, which subsequently, is thought to contribute to the onset of depression in PD patients.