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TWEAKR Recombinant Rabbit Monoclonal Antibody [SN20-07] (ET1611-93)

Price: Regular price $385.00

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Catalog# ET1611-93

Rabbit Monoclonal to TWEAKR

Tested for

  • WB

  • IHC-P

  • IP

Reacts with

  • Human

  • Mouse

  • Rat

Recombinant production enables lot-to-lot consistency and is animal-cruelty-free
This product has been cited in peer reviewed publications, see list HERE

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Specifications

Product Type

Recombinant Rabbit monoclonal primary

Product Name

TWEAKR Recombinant Rabbit Monoclonal Antibody [SN20-07] (ET1611-93)

Immunogen

Synthetic peptide within human tweakr aa 80-129 / 129.

Host

Rabbit

Positive Control

NIH/3T3 cell lysates , C2C12 cell lysates, mouse uterus tissue.

Conjugation

Unconjugated

Clonality

Monoclonal

Clone Number

SN20-07

RRID

AB_3070074

APPLICATION DILUTION

  • WB

  • 1:500-1:1,000

  • IHC-P

  • 1:50-1:200

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1ug/ul

Purification

Protein A affinity purified.

Molecular Weight

14 kDa

Isotype

IgG

TARGET

UNIPROT #

Q9NP84

PROTEIN NAME

TWEAKR

SYNONYMS

CD 266 antibody;CD266 antibody;CD266 antigen antibody;FGF inducible 14 antibody;FGF-inducible 14 antibody;Fibroblast growth factor inducible immediate early response protein 14 antibody;Fibroblast growth factor-inducible immediate-early response protein 14 antibody;FN 14 antibody;FN14 antibody;TNFRSF 12A antibody;TNFRSF12A antibody;TNR12_HUMAN antibody;Tumor necrosis factor receptor superfamily member 12A antibody;TWEAK R antibody;Tweak receptor antibody;Tweak-receptor antibody;TweakR antibody

TISSUE SPECIFICITY

Highly expressed in heart, placenta and kidney. Intermediate expression in lung, skeletal muscle and pancreas.

SUBCELLULAR LOCATION

Membrane.

FUNCTION

Fn14, the TWEAK receptor, is a recently identified member of the TNF receptor superfamily and is expressed on smooth muscle cells and endothelial cells. It is a weak inducer of apoptosis and promotes angiogenesis. Fn14 is a type 1 membrane protein. It associates with TRAF1 and TRAF2, and may modulate cellular adhesion to matrix proteins. Fn14 is highly expressed in heart, placenta and kidney, and moderately expressed in lung, skeletal muscle and pancreas. It is the smallest member of the TNF receptor (TNFR) superfamily described to date, and signals via recruitment of several different TNFR-associated factors.

CITATIONS

  • J Qian,et al

    The CD163/TWEAK/Fn14 axis: A potential therapeutic target for alleviating inflammatory bone loss

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